Sunday, December 2, 2012

Cars trapped in tunnel collapse outside Tokyo

TOKYO (AP) ? Parts of a tunnel collapsed Sunday on a highway west of Tokyo, trapping an unknown number of vehicles as smoke from a fire inside initially prevented rescuers from approaching.

Video footage from cameras inside the tunnel, after the fire was apparently extinguished, showed firefighters picking their way through cement roof panels that collapsed onto vehicles inside the Sasago Tunnel, about 50 miles (80 kilometers) outside the city.

About 25 vehicles were inside the (2.5 mile) 4.3 kilometer-long tunnel, some of them trucks stopped by the tunnel's collapse.

Police spokesman Yoshihiro Fukutani said they were still seeking details about the situation inside the tunnel.

Police vehicles, fire trucks and ambulances were massed outside the tunnel's entrance. A man who said he saw the collapse and alerted authorities to the emergency told NHK television he managed to escape after he was ordered to flee. The roof and windows of another vehicle parked on the roadside outside the tunnel were crushed, and the injured occupants reportedly taken to a hospital.

Source: http://news.yahoo.com/cars-trapped-tunnel-collapse-outside-tokyo-024529497.html

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Saturday, December 1, 2012

Panel to eye links between cycling body, Armstrong

GENEVA (AP) ? An independent panel will examine possible links between cycling's governing body and the Lance Armstrong doping case.

The three-member panel will meet in London from April 9-26, with a June 1 deadline to deliver its report.

The group consists of retired British judge Philip Otton, Australian lawyer Malcolm Holmes and former Paralympics star Tanni Grey-Thompson. They were appointed by John Coates, president of the Court of Arbitration for Sport.

"The appointment of these three eminent figures demonstrates clearly that the UCI wants to get to the bottom of the Lance Armstrong affair and put cycling back on the right track," Pat McQuaid, president of the International Cycling Union, said in a statement Friday. "We will listen to and act on the commission's recommendations."

Otton's sports legal cases include a Premier League relegation dispute involve Carlos Tevez, and Chelsea's tactics in trying to lure Ashley Cole from Arsenal. Grey-Thompson, a 10-time Paralympic gold medalist in wheelchair racing, is now a lawmaker in the upper chamber of Britain's Parliament.

The cycling body said the three will have access to "all relevant documents in the control or possession of the UCI," including bank and telephone records and laboratory test results.

The announcement came two days before a group of the UCI's and Armstrong's fiercest critics, including three-time Tour de France winner Greg LeMond, meets in London to press for changes in how cycling is run.

The UCI asked Coates last month to help create a panel to investigate suspicions raised by the U.S. Anti-Doping Agency's damning report into widespread doping by Armstrong's teams during his record seven Tour wins from 1999-2005. Armstrong was stripped of seven Tour de France titles and banned for life.

The panel's work could be key in determining whether the governing body can rebuild its damaged credibility. The commission will scrutinize McQuaid, who was elected as UCI president weeks after Armstrong first retired in 2005, and his predecessor, Hein Verbruggen, in their relations with Armstrong.

The governing body denies claims made by former Armstrong teammates to USADA that it covered up suspicious samples from Armstrong in exchange for payments totaling $125,000, or that the American rider enjoyed special protection.

"The commission's report and recommendations are critical to restoring confidence in the sport of cycling and in the UCI as its governing body," McQuaid said. "We will cooperate fully with the commission and provide them with whatever they need to conduct their inquiry and we urge all other interested stakeholders to do the same."

The UCI pledged to fund the commission's work and will be legally represented at the London hearings. It did not specify if sessions will be public.

McQuaid said the cost of the commission will be a "significant burden" on his organization.

"However, it is clear that only such a decisive and transparent examination of the past will answer our critics by thoroughly examining our assertion that the UCI's anti-doping procedures are and have been among the most innovative and stringent in sport," he said.

The panel will examine whether the UCI's doping rules were "inadequate or were not enforced with sufficient rigor"; if the UCI had "any reliable evidence or information" that Armstrong was doping; and if it "adequately cooperated with, assisted in and reacted to the USADA" investigation.

A potential conflict of interest between the UCI's role promoting the sport and its duty to police doping will also be examined.

Following the USADA report, LeMond denounced McQuaid and Verbruggen as "the corrupt part of the sport" and called on them to leave the UCI.

LeMond, now the only American winner of cycling's biggest prize, will be joined in London by journalists Paul Kimmage and David Walsh and Australian anti-doping scientist Michael Ashenden, who helped the UCI develop its biological passport anti-doping project.

Under the "Change Cycling Now" banner, the group will meet over two days.

Source: http://news.yahoo.com/panel-eye-links-between-cycling-body-armstrong-182145081--spt.html

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BookBook for iPhone 5 now shipping, rear camera hole and all (hands-on)

BookBook for iPhone 5 now shipping, rear camera hole and all handson

It took a little longer than some of those other cases, but Twelve South's BookBook for iPhone 5 is now shipping en masse. Some of those who pre-ordered began receiving their units as early as last week, but if you missed that wave, there's no need to gesture for the panic button. The outfit's newest wallet / iPhone case is actually more than just a resized version of the prior one; indeed, it finally figured out how to add a rear camera hole without worry of flash echo, and there's a new snap-in mechanism that holds your phone in place. The clever exterior remains largely the same, and there's still room for your most important IDs and credit cards as you flip it open. We were pretty big fans of the prior build, but the addition of the camera hole makes this one a no-brainer for fans of the style. The gallery below is completely free to peruse -- those who hit the source link, however, will be asked to fork over $59.99 to get one of their own.

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Source: Twelve South


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ZfIbA3pLffI/

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U.S. launches new project to develop electric-vehicle batteries

WASHINGTON | Fri Nov 30, 2012 2:13pm EST

WASHINGTON (Reuters) - The Obama administration launched a fresh $120-million research project Friday, aimed at developing cheaper batteries for electric vehicles, a sector that has faltered despite billions of dollars of prior government investment.

The Energy Department will dole out the money over five years to establish a research hub for batteries and energy storage, backed by five national laboratories, five Midwestern universities and four private firms.

The four companies joining the project are Dow Chemical Co, Applied Materials Inc, Johnson Controls Inc and Clean Energy Trust.

During the Obama administration's first term, jump-starting advanced battery manufacturing was a major national initiative, which saw the Energy Department plow $2 billion of grants into 29 battery makers to build or update plants.

But the industry was hobbled by overcapacity, limp demand for electric vehicles and high-profile bankruptcies, including the collapse of government-backed battery maker A123.

Still, the government defended its efforts, saying that despite some failures, most of its investments were successful and helped double renewable-energy output from wind and solar.

"Not every company succeeds," Energy Secretary Steven Chu said at a news conference Friday announcing the new project. "Never should the United States say because one company didn't succeed as much as others, we should get out of the game."

Led by the Argonne National Laboratory near Chicago, the new research hub will combine several independent research programs into a single coordinated effort "to push the limits on battery advances," the department said.

Besides working on batteries for electric vehicles, the project will also tackle energy storage for the electric grid, officials said.

Many Republicans have attacked the Obama administration's direct investment in clean energy companies, arguing that the government should not be in the business of picking winners and losers in the private sector.

However, government investment in energy research and development still has broad bipartisan support in Congress.

(Editing by Bernadette Baum)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/kMjY0OyfmB8/us-usa-batteries-research-idUSBRE8AT14Z20121130

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Study helps resolve debate about how tumors spread

Friday, November 30, 2012

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, has shown for the first time how cancer cells control the ON/OFF switch of a program used by developing embryos to effectively metastasize in vivo, breaking free and spreading to other parts of the body, where they can proliferate and grow into secondary tumors.

The findings are published in the December 11 issue of the journal Cancer Cell.

In 90 percent of cancer deaths, it is the spreading of cancer, known as metastasis, which ultimately kills the patient by impacting ever-more tissues and functions until the body fails. Ten years ago, a French cancer researcher named Jean Paul Thiery hypothesized that tumor cells metastasized by exploiting a developmental process known as epithelial-to-mesenchymal transition or EMT.

EMT is seen in developing embryos whose cells transform from stationary epithelial cells into more mobile mesenchymal cells, the latter able to migrate to new locations and create new types of tissue and organs. Thiery proposed that cancer cells also switch "ON" EMT, temporarily changing attributes so that they can detach from primary tumors, enter the bloodstream and seed new tumors elsewhere. After arriving at a new location, the cancer cells then turn "OFF" the EMT program and grow into carcinoma metastases or tumors.

Thiery's hypothesis was controversial because researchers haven't been able to find supporting evidential proof in vivo. "Although this model was proposed in 2002, there have been no experiments done to attest to it in a spontaneous tumor model," said Jing Yang, PhD, associate professor of pharmacology and pediatrics and senior author of the Cancer Cell paper. "Our new study provides an in vivo demonstration of the reversible EMT in metastasis and helps to resolve the controversy on this leading theory in metastasis."

Using a mouse squamous cell carcinoma model, Jeff Tsai, PhD, a postdoctoral fellow in Yang's lab and first author of the study, with help from collaborators at the Whitehead Institute for Biomedical Research in Cambridge, MA and The Sanford-Burnham Medical Research Institute in La Jolla, showed that activation of an EMT-inducing gene called Twist1 is sufficient to turn "ON" the EMT switch and promote carcinoma cells to disseminate into blood circulation. Equally importantly, the researchers found that turning "OFF" the EMT switch at distant sites is essential for disseminated tumor cells to proliferate and form metastases. Their findings indicate that reversible EMT likely represents a key driving force in human carcinoma metastasis.

"There are many similarities between developmental EMT and EMT in metastasis," Yang said. "Both processes seem to use the same cellular machineries and signaling pathways to activate the EMT program. During embryogenesis, the EMT program tends to be more permanent and epithelial cells commit to a mesenchymal fate. Our study shows that carcinoma cells need a reversible EMT to achieve efficient metastasis. It suggests that EMT reversion could be a critical step to wake up tumor cells from dormancy, a phenomenon in which cancer patients develop metastasis years after the initial primary tumor diagnosis and removal."

It's not entirely known how Twist1 becomes active in primary tumors, though previous studies have pointed to factors like hypoxia and inflammation in the tumor microenvironment. Researchers do not know exactly how Twist1 is "turned off at distant organs." Yang said these are subjects of current experiments.

More broadly, the published findings suggest that more research is needed to determine how to target EMT to combat cancer metastasis. Several pharmaceuticals and research institutes are already pursuing EMT inhibitors as possible cancer treatments.

"Since reversion of EMT promotes colonization and growth of metastases, this study actually cautions that therapies inhibiting EMT could be counterproductive in preventing distant metastases when patients already present circulating tumor cells. Instead, blocking EMT reversion may prevent dormant tumor cells from establishing metastases."

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125602/Study_helps_resolve_debate_about_how_tumors_spread

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DePaul Gay and Lesbian Office Site Links to Pro-Gay ?Marriage ...

The Facebook site of the Office of LGBTQA Student Services?at DePaul?University is filled with gay ?marriage? propaganda and even links to a site that urges Facebook to?recognize the Polyamorous.

The Office of Lesbian, Gay, Bisexual, Transgender, Questioning, Queer and Ally (LGBTQA) Student Services at DePaul University was created as an effort by the university to create a ?more comprehensive approach to supporting LGBTQ?students on campus? and boasts that ?the?Office of LGBTQA Student Services will also allow the university to continue its evolution and become a more?progressive, diverse, and supportive community.?

The DePaul?LGBTQA Student Service?s Facebook site links to a news report of Chicago Mayor Rahm Emanuel saying ?The time is now? for gay ?marriage,? shares a poster congratulating Spain for legalizing gay ?marriage? and even urged people to vote for gay ?marriage??on election day saying ?support equality!?

The Office of LGBTQA Student Services site also links to a site called ?Polyamory for Facebook? that?urges Facebook to allow more than one name in the relationship status box as a way of being sensitive to those who take part in polyamorous relationships. That site explains it this way:

This page is created for awareness & love. The thought behind it is that Facebook does not have the option to add more th(a)n one person to your relationship status, also the option of open relationship does not suit the nature of polyamorous?relationships. So my suggestion is, promote this page, & write the staff of face book letting them know we want the features added. The ability to add more th(a)n one person & a general Poly relationship status.

DePaul did not respond to questions from The Cardinal Newman Society.

Source: http://blog.cardinalnewmansociety.org/2012/11/29/depaul-gay-and-lesbian-office-site-links-to-pro-gay-marriage-and-even-pro-polyamorous-site/

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iPad Pinball Game Console - Headlines & Heroes

iPad Pinball Game Console

Arcade Fire

Between the Throwdown Bed and Brew Cave Walk-In Beer Cooler & Kegerator you?re running out of space in your pad. As much as you love the old school pinball machine you inherited from your frat house, something has to go. Fortunately, you can still get the same jollies from the iPad Pinball Game Console ($60.00) without giving up any real estate. The wireless controller features a spring-loaded plunger and flipper buttons that recreate the arcade experience with your iPad. You can tilt the screen to get the most pinball-friendly angle and the console also adds bump and tilt mechanisms during gameplay. The Duo Pinball works in conjunction with the free Pinball HD Collection app, which comes with 5 free pinball tables ? Play Wild West, The Deep, Snow, DaVinci, and Jungle Style, all stacked with rich audio and visuals. The only downside is that you can?t play flip cup on it or use it as an impromptu make out spot?but that?s what the Throwdown Bed is for.

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Source: http://headlinesandheroes.com/gadgets/ipad-pinball-game-console/

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